Register Enterprise Geodatabase with ArcGIS Enterprise

In order for ArcGIS Enterprise to communicate with the database, ArcGIS Enterprise must have a 'trusted connection' to the database. This is done via 'data store registration.'

Once you have created the Enterprise Geodatabase and added the appropriate service account to the database, you can then generate an .sde file, which is Esri's proprietary connection format built from the .odbc standard. Once you have an .sde file, you can then navigate to the ArcGIS Server Site and following the instructions written on Esri's documentation page.

Esri's documentation on registering data stores with ArcGIS Server can be found here.